As the commentaries reveal, cognitive neuroscience's first steps toward a theory of development are marked by vigorous debate, ranging from basic points of definition to the fine details of mechanism. In this Response, we present the neural constructivist position on this broad spectrum of issues, from basic questions such as what sets constructivism apart from other theories (particularly selectionism) to its relation to behavioral theories and to its underlying mechanisms. We conclude that the real value of global theories at this (...) stage of cognitive neuroscience is not just their answers but the new set of research questions they pose. (shrink)

How do minds emerge from developing brains? According to the representational features of cortex are built from the dynamic interaction between neural growth mechanisms and environmentally derived neural activity. Contrary to popular selectionist models that emphasize regressive mechanisms, the neurobiological evidence suggests that this growth is a progressive increase in the representational properties of cortex. The interaction between the environment and neural growth results in a flexible type of learning: minimizes the need for prespecification in accordance with recent neurobiological evidence (...) that the developing cerebral cortex is largely free of domain-specific structure. Instead, the representational properties of cortex are built by the nature of the problem domain confronting it. This uniquely powerful and general learning strategy undermines the central assumption of classical learnability theory, that the learning properties of a system can be deduced from a fixed computational architecture. Neural constructivism suggests that the evolutionary emergence of neocortex in mammals is a progression toward more flexible representational structures, in contrast to the popular view of cortical evolution as an increase in innate, specialized circuits. Human cortical postnatal development is also more extensive and protracted than generally supposed, suggesting that cortex has evolved so as to maximize the capacity of environmental structure to shape its structure and function through constructive learning. (shrink)

The philosophical innateness debate has long relied onpsychological evidence. For a century, however, a parallel debate hastaken place within neuroscience. In this paper, I consider theimplications of this neuroscience debate for the philosophicalinnateness debate. By combining the tools of theoretical neurobiologyand learning theory, I introduce the ``problem of development'' that alladaptive systems must solve, and suggest how responses to this problemcan demarcate a number of innateness proposals. From this perspective, Isuggest that the majority of natural systems are in fact innate. (...) Lastly,I consider the acquistion strategies implemented by the human brain andsuggest that there is a rigorous way of characterizing these ``neuralconstructivist'' strategies as not being strongly innate. Alternatives toinnateness are thus both rigorously definable and empirically supported. (shrink)

Experimental philosophy is a relatively recent discipline that employs experimental methods to investigate the intuitions, concepts, and assumptions behind traditional philosophical arguments, problems, and theories. While experimental philosophy initially served to interrogate the role that intuitions play in philosophy, it has since branched out to bring empirical methods to bear on problems within a variety of traditional areas of philosophy—including metaphysics, philosophy of language, philosophy of mind, and epistemology. To date, no connection has been made between developments in experimental philosophy (...) and philosophy of technology. In this paper, I develop and defend a research program for an experimental philosophy of technology. (shrink)

This study examines the moral and ethical arguments presented by public relations practitioners in online debate on the appropriateness of representing the tobacco industry or tobacco interests. It is a descriptive and inferential analysis of 21 e-mail messages posted during a 14-month debate on the PRForum, an online newsgroup for public relations professionals, applying Kohlberg's cognitive-development theory of moralization. Debate focused on the right of an organization to promote a legal product versus a practitioner's obligation to protect the welfare of (...) society. Intensity of disagreement, and the inability to achieve consensus, suggests that personal ethical baselines are subjective, that practitioner perceptions of right or wrong are injluenced by their level of cognitive and moral development, and that codes of behavior of professional organizations are too ambiguous to use in dealing with complex ethical issues. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mild Cognitive Impairment:What's in a Name?Steven R. Sabat (bio)Keywordslabeling, mild cognitive impairment, recall memory, selfhood, stereotype threatCorner and Bond (2006) raise a number of important conceptual issues related to the problems involved in defining mild cognitive impairment (MCI), differentiating it from normal aging, the definition of normal aging itself, and ethical issues surrounding the possible adverse effects of a diagnosis of MCI on the individuals thus described. It (...) would seem that portentous ramifications are involved and that clarifying the conceptual issues would be of great value, not only to researchers but also to the ever-growing population of elderly people. In what follows, I address some of these issues further.Problems of Definition and MeasurementOne of the problems that the authors discuss at the outset of their article concerns what methods are appropriate for detecting those with MCI: "Neuropsychological tests alone do not discriminate between normal aged-related memory loss and MCI or dementia and clinical judgment remains central to diagnosis" (Corner and Bond 2006, 5). Of course, to be able to discriminate between normal aged-related memory problems and MCI, we must first be able to define the former. What exactly is normal? As the authors correctly point out, the term has different meanings, one being normative (usual), another being nonpathologic. Is it normal (usual) for some sort of breakdown to occur in brain systems as a function of increased age? If so, is there a threshold age below which the very same physiologic breakdown is unusual? Would such a threshold age, if one existed, be the same for everyone, regardless of genotype and the cumulative interactive effects of nutrition, health, and stress-related factors over a period of decades? In effect, is some sort of memory impairment part of the natural (usual) process of aging for some people at particular ages rather than for others? And exactly what does it mean to be mildly impaired in the cognitive domain?Hogan and McKeith (2001) presented a working group's definition characterizing MCI such that people who complain about memory problems and who also provide objective evidence of such problems, yet who simultaneously display "normal general cognitive function and intact activities of daily living" (Hogan and McKeith 2001, 1131), should be identified and followed. Here again, however, we confront the problem of defining "normal general cognitive function" as well as "normal activities of daily living." Can one have normal general cognitive function without normal memory function? If so, what exactly constitutes [End Page 13] general cognitive function and on what conceptual or theoretical basis is such a definition valid? Furthermore, what sort of memory function are we talking about? Memory can be said to involve a number of stages: encoding, storage, and retrieval. Retrieval can be of the explicit type (conscious recall or recognition of specific information) with which people with Alzheimer's disease (AD) often reveal deficits or of the implicit type (a change in behavior as a result of previous experience of which the person may have no conscious recollection) as demonstrated in people with AD (Knopman and Nissen 1987). That is, people with AD can display deficits in explicit memory functions without similar deficits simultaneously in implicit memory functions.A partial answer to the question about memory loss in MCI may be found in the use of the Mini-Mental State Examination (MMSE; Folstein, Folstein, and McHugh 1975), originally intended to be used as a screening device, but employed more and more frequently as an outcome measure to assess cognitive decline as well as the efficacy of drug treatments. Although the examination purports to test orientation, registration, attention, calculation, recall, language (naming, repeating, reading, writing, three-stage command), and construction, a task analysis reveals that the test is not quite as "global" in the cognitive domain as it is purported to be. For example, ten of the maximum thirty points on the examination are earned for "orientation" in time and place. Yet, all of the questions in this section of the test require intact recall of the relevant information. For example, if a person is asked, "What day of the week is this?" and replies "I don't know," the... (shrink)

Van Gelder seeks to distinguish between the computational and the dynamical hypotheses primarily on the basis of ontic criteria – the kind of systems cognitive agents really are. I suggest that this meets with mixed success. By shifting to epistemic criteria – what kind of explanations we require to understand cognitive agents – I suggest there is an easier and more intuitive way to distinguish between these two competing views of cognitive agents.

This volume is an introduction to the underpinnings of journalism ethics, and a guide for journalists and journalism teachers looking for ways to form consistent and informed ethical decisions.

International law and ethics share a common goal of helping us understand the norms and institutions needed to promote a just world order. Yet each of the two fields has approached this shared task with little regard for the insights of other, and interdisciplinary collaboration is now imperative. This essay shows the complementary nature of inquiries in political and moral philosophy, on the one hand, and international law, on the other, by examining the so-called New Haven School (or policy-oriented jurisprudence), (...) an international law method that explicitly considers values as both inputs and outputs of the process of making law. It finds that the School’s sociological orientation does not adequately integrate ethical inquiries essential to prescribing law, in particular questions about the scope of duties that individuals and states owe those abroad. Using the current legal debate over the extraterritorial application of human rights as an example, the paper shows how approaches from moral and political philosophy can help provide a rigorous and principled basis for the prescription of law, as well as link seemingly unrelated questions of international law to each other. (shrink)

In this article, I explore how methods of investigation can allow us either to appreciate the intact cognitive and social abilities of people with Alzheimer’s disease or unwittingly obscure those same abilities. Specifically, I shall assert that (1) the biomedical- quantitative approach, while being generally appropriate for drug efficacy studies, does not allow us to appreciate the many significant strengths possessed by people diagnosed with dementia, (2) qualitative/narrative approaches do so admirably, and (3) understanding the cognitive and social strengths of (...) people diagnosed is of paramount importance for developing optimal care giving approaches and reveals strikingly the shared humanity of those diagnosed with dementia and those deemed healthy. (shrink)

This article presents a critique of an article previously featured in Nursing Philosophy (10: 26–33) by Ursula Naue and Thilo Kroll, who suggested that people living with dementia are assigned a negative status upon receipt of a diagnosis, holding the identity of the ‘demented other’. Specifically, in this critique, we suggest that unwitting use of the adjective ‘demented’ to define a person living with the condition is ill-informed and runs a risk of defining people through negative (self-)attributes, which has a (...) deleterious impact upon that person's social and relational personae. Moreover, use of the locution ‘demented’ reinforces a divide between the ‘demented’ (them) and the ‘healthy others’ (us). Social constructionist theory, malignant positioning and viewing people with dementia as semiotic subjects are the philosophical pillars through which we construct the main arguments of the critique. The article concludes with the voice of one of the authors, a younger person with dementia, asking for language in dementia care to be carefully reconsidered and reframed and for the recognition of the diagnosed person's agency in the conduct of their day-to-day lives. (shrink)

The insanity defense presents many difficult questions for the legal system. It attracts attention beyond its practical significance (it is seldom used successfully) because it goes to the heart of the concept of legal responsibility. “Not guilty by reason of insanity” generally requires that as a result of mental illness the defendant was unable to distinguish right from wrong at the time of the crime. The many difficult and complex questions presented by the insanity defense have led some in the (...) legal community to hope that neuroscience might help resolve some of these problems, but that hope is not likely to be realized. (shrink)

The most important election held in 2001 was that to the House of Councillors. Here, however, I will report on several surprising gubernatorial elections and the shocking LDP party presidential election. Each of these elections sent a similar message from the voters: . Powerful political machines using tried and true campaign techniques were repeatedly defeated by novices whose primary attraction was that they were not part of the political establishment.

This up-to-date collection of more than two dozen real-life cases illustrates the moral issues facing contemporary American journalists. It will help students hone their reasoning skills, encouraging them to think rationally and act with integrity.

Robotization is an increasingly pervasive feature of our lives. Robots with high degrees of autonomy may cause harm, yet in sufciently complex systems neither the robots nor the human developers may be candidates for moral blame. John Danaher has recently argued that this may lead to a retribution gap, where the human desire for retribution faces a lack of appropriate subjects for retributive blame. The potential social and moral implications of a retribution gap are considerable. I argue that the retributive (...) intuitions that feed into retribution gaps are best understood as deontological intuitions. I apply a debunking argument for deontological intuitions in order to show that retributive intuitions cannot be used to justify retributive punishment in cases of robot harm without clear candidates for blame. The fundamental moral question thus becomes what we ought to do with these retributive intuitions, given that they do not justify retribution. I draw a parallel from recent work on implicit biases to make a case for taking moral responsibility for retributive intuitions. In the same way that we can exert some form of control over our unwanted implicit biases, we can and should do so for unjustifed retributive intuitions in cases of robot harm. (shrink)

The codification of international human rights law and international humanitarian law, and the accession to those treaties by a large majority of states, does not at first glance seem to have any significant effect upon states' behavior in situations of crisis. Any understanding of the prospects for such law in these situations requires an appraisal of both the motivations of states in concluding these treaties and the pressures on them to ignore them. This paper analyzes those motivations and temptations through (...) the framework of precommitment theory, a component of rational choice theory, originally articulated by Jon Elster and Thomas Schelling. The metaphor of Ulysses offers a useful way to address three different dimensions of the purposes that states join treaties: beliefs, i.e., the state's attitude toward the norms in the treaty; predictions, the state's concerns about its own future behavior; and interactions, i.e., the extent to which the state is trying to influence or bind other states. And it permits linking those motivations to the propensity of states to comply at a later time. The paper offers a four-part typology for why states commit to such treaties, contrasting it with notions from contemporary international relations theories. It then explores the contrasting approaches of compliance theories and international law doctrine to the temptation of states to violate treaties and elaborates the contributions of the precommitment framework. Building upon that framework, it proposes a set of strategies that those concerned with compliance might explore for making international law more relevant when governments seem most inclined to discount it. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Trungpa's Barbarians and Merton's Titan:Resuming a Dialogue on Spiritual EgotismSteven R. ShippeeA Dialogue Begun: The Meeting of Chögyam Trungpa and Thomas MertonMuch of the dialogue on the spiritual life between Buddhists and Christians has centered on two locations in the United States. The first is Naropa Institute (now University) in Boulder, Colorado. This institution was founded in 1974 by Chögyam Trungpa, a Tibetan master and lineage holder of both (...) the Nyingma and Kagyü traditions, two of the four major schools of Tibetan Buddhism. Under Trungpa's guidance, Naropa hosted an important series of Buddhist-Christian contemplative dialogues in the 1980s.1 A second significant place is Gethsemani Abbey in Kentucky, the Trappist monastery that became home to Thomas Merton in 1941. Since 1996, and through the efforts of several of the same people who had worked on the Naropa dialogues, the abbey has hosted three interreligious "encounters" sponsored by the Monastic Interreligious Dialogue.2An important link between these dialogues, as well as the initial inspiration for the first of them,3 is the meeting of the two men most famously associated with each of the hosting institutions, Trungpa and Merton. As many of their respective readers know, the two men met in Calcutta on 19 October 1968, and spent several days together.4 This contact was very stimulating to them both and seemed the beginning of a deep friendship. Merton was so impressed with Trungpa that he immediately determined to visit Trungpa's new monastery in Scotland. Trungpa later said, "Meeting Thomas Merton was wonderful,"5 and that he felt he "was meeting an old friend, a genuine friend."6 Despite the brevity of their relationship, during his last talk on 10 December, Merton said he likewise considered Trungpa "a good friend."7 Later that same day, their friendship and dialogue were terminated by Merton's death. Not two months had passed since the meeting in Calcutta. Trungpa called Merton's death "a tremendous loss, to me personally and to the world of genuine spirituality."8Judith Simmer-Brown has provided the fullest picture thus far of the relationship between Trungpa and Merton.9 One of the facts that most intrigues Trungpa's [End Page 109] followers is his own recollection, shared with participants at the third Naropa dialogue, that the two discussed what he called "spiritual materialism" (his most common phrase for spirituality co-opted by ego) at some length over dinner and drinks.10 This article picks up where that recollection leaves off. While we do not know more about the specific content of that discussion, we do have a body of writings from each man on topics relating to the quest and pitfalls of authentic spirituality. A comparative analysis of these proves worthwhile, as further elucidation of what made possible their meeting of the minds and the immediate affection they felt for each other, and certainly as wisdom that still has the power to deepen our spiritual experience today by exposing the manipulations and deceptions to which ego11 subjects even our noblest spiritual aspirations.The challenges to authentic spiritual life were major concerns for both Trungpa and Merton, a leitmotif that characterized almost all of their respective teachings and written works.12 As an extensive examination of these is not possible here, I have set side by side one symbol from each: Trungpa's modification of the traditional Tibetan teachings on the Lalos (kla.klo, literally "barbarians"), which he translated as the "Three Lords of Materialism," and Merton's reflections on the tragic Titan Prometheus, who stole fire from the gods. These two symbols, while certainly not exhaustive of their insights, nonetheless effectively crystallize their respective thoughts on the matter, and thereby allow us to see that Trungpa and Merton shared very striking insights both about the malady of spiritual egotism and about its necessary antidotes.Chögyam Trungpa on Spiritual MaterialismIn talks given from 1970 to 1973, Trungpa gave teachings to his students on "the Three Lords of Materialism," symbolic personifications of the trap to which he referred as spiritual materialism.13 Believing that most of his students were sincere about the spiritual path, he... (shrink)

As an emerging discipline, neuroeconomics faces considerable methodological and practical challenges. In this paper, I suggest that these challenges can be understood by exploring the similarities and dissimilarities between the emergence of neuroeconomics and the emergence of cognitive and computational neuroscience two decades ago. From these parallels, I suggest the major challenge facing theory formation in the neural and behavioural sciences is that of being under-constrained by data, making a detailed understanding of physical implementation necessary for theory construction in neuroeconomics. (...) Rather than following a top-down strategy, neuroeconomists should be pragmatic in the use of available data from animal models, information regarding neural pathways and projections, computational models of neural function, functional imaging and behavioural data. By providing convergent evidence across multiple levels of organization, neuroeconomics will have its most promising prospects of success. (shrink)

Governments around the world have faced the challenge of how to respond to the recent outbreak of a novel coronavirus disease. Some have reacted by greatly restricting the freedom of citizens, while others have opted for less drastic policies. In this paper, I draw a parallel with vaccination ethics to conceptualize two distinct approaches to COVID-19 that I call altruistic and lockdown. Given that the individual measures necessary to limit the spread of the virus can in principle be achieved voluntarily (...) as well as through enforcement, the question arises of how much freedom governments ought to give citizens to adopt the required measures. I argue that an altruistic approach is preferable on moral grounds: it preserves important citizen freedoms, avoids a number of potential injustices, and gives people a much-needed sense of meaning in precarious times. (shrink)

Bioethics, Volume 36, Issue 6, Page 687-698, July 2022.

Interest in the role of nitric oxide (NO) in the nervous system began with the demonstration that glutamate receptor activation in cerebellar slices causes the formation of a diffusible messenger with properties similar to those of the endothelium-derived relaxing factor. It is now clear that this is due to the Ca2+/calmodulin-dependent activation of the enzyme NO synthase, which forms NO and citrulline from the amino acid L-arginine. The cerebellum has very high levels of NO synthase, and although it has low (...) levels of guanylyl cyclase, cerebellar cyclic guanosine monophosphate (cGMP) levels are an order of magnitude higher than in other brain regions. A transcellular metabolic pathway is also present in the cerebellar cortex to recycle citrulline back to arginine. The NO formed binds to and activates soluble guanylyl cyclase to elevate cGMP levels in target cells. Studies employing NADPH-diaphorase, a selective histochemical marker for NO synthase, together with immunohistochemistry, in situ hybridization and biochemical studies have indicated that NO production occurs in granule and basket cells in the cerebellar cortex, whereas cGMP formation appears to occur largely in other cells, including Purkinje cells. Given that a long-term depression of AMPA currents can be seen in isolated Purkinje cells, this anatomical localization suggests that NO cannot play an essential role in the induction of this form of synaptic plasticity. (shrink)

Moralization is a social-psychological process through which morally neutral issues take on moral significance. Often linked to health and disease, moralization may sometimes lead to good outcomes; yet moralization is often detrimental to individuals and to society as a whole. It is therefore important to be able to identify when moralization is inappropriate. In this paper, we offer a systematic normative approach to the evaluation of moralization. We introduce and develop the concept of ‘mismoralization’, which is when moralization is metaethically (...) unjustified. In order to identify mismoralization, we argue that one must engage in metaethical analysis of moralization processes while paying close attention to the relevant facts. We briefly discuss one historical example and two contemporary cases related to COVID-19 that we contend to have been mismoralized in public health. We propose a remedy of de-moralization that begins by identifying mismoralization and that proceeds by neutralizing inapt moral content. De-moralization calls for epistemic and moral humility. It should lead us to pull away from our tendency to moralize—as individuals and as social groups—whenever and wherever moralization is unjustified. (shrink)

Preventive vaccination can protect not just vaccinated individuals, but also others, which is often a central point in discussions about vaccination. To date, there has been no systematic study of self- and other-directed motives behind vaccination. This article has two major goals: first, to examine and distinguish between self- and other-directed motives behind vaccination, especially with regard to vaccinating for the sake of third parties, and second, to explore some ways in which this approach can help to clarify and guide (...) vaccination debates and policy. I propose conceiving of vaccination in terms of three basic elements: the vaccination decision-maker, the vaccine recipient and the primary beneficiary. I develop a taxonomy based on the relations between these elements to distinguish four kinds of vaccination: self-protective, paternalistic, altruistic and indirect. I finally discuss the case of human papillomavirus vaccine regulation for men and women to show how each kind of vaccination is associated with and raises specific ethical questions. (shrink)